LESLIE B. RASCHKA M.D. TRIED TO WARN OTHERS ABOUT THE PATERNAL AGE EFFECT BEFORE DR. MALASPINA'S 2001 PAPER
Abstract
Purpose: To assess the role of paternal age in the origin of genetic illness in future generations.
Data Sources: All reference data originated in English language international scientific literature and findings of original research conducted by myself.
Study Selection: Original articles published between 1938 and 1998 were selected according to the stated purpose. One article was written by myself.
Data Extraction: The present paper deals with 4 subtopics: andrology, genetics, pathology, and psychiatry.
Results: Nine articles reporting on 1399 patients described the deterioration of the quality of semen related to ageing. Five articles reported an increased mutation rate in the male germ cells as compared to the female germ cell. Twenty-four articles reported on 1230 patients and related studies described paternal age effect on increased mutation rate causing genetic illness. Eight articles reporting on 10,347 patients described increased prevalence of mental illness as related to older paternal age.
Conclusions: The age of the father is an important determinant of the health of future generations. Children conceived by fathers older than 34 years of age are at increased risk for genetic illness due to recent mutation in the male germ cell.
3The genetic illness of a child could originate in a mutation related to the age of the father or to a mutation in the spermatogenesis caused by ageing in previous generations. The ageing process in the male is an important, probably the most important, cause of genetic illness in human populations.
Labels: children conceived by older fathers are at increased risk of genetic illness due to a recent mutation in the male germ line, Leslie B. Raschka, M.D.
posted by concerned heart @ 6:47 PM
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Hi - I've been reading your stuff for awhile now. I have Treacher Collins; my brother does, as well as my 13 yr old daughter. I wanted to pick your brain on many things to do with the genetics of this. Basically for right now - it was me who passed TCS on; I was 37 and he was 47, but I'm the one with the TCS mutation. After the fact, I was told that my older maternal age probably had much to do with it (older eggs) in the 50/50 chance. Did his age add to my 50/50 chance? I wish there was a way to converse in email with you as I have many topics regarding genetics on TCS that I would love to talk about. One is that I am seeing a very high incidence of (spontaneous) TCS in in-vitro births - one twin with TCS and one without. Any thoughts on what is happening in the in-vitro process to cause the mutation change? I can 'see' how interfering with the process could cause a mutation change but I wish we understood more about this. We are able to see this high incidence of it on our TCS group but doctors only see one or two cases in their lifetime probably, so no one probably knows it's going on. Would you have any comments?
Thanks,
Judy
Dear Judy,
Your TCS most likely came from your dad. Was he older when you and your brother were born or did he work in a field where he was exposed to toxins? Your daughter had a 50/50 chance because you have the mutation in 50% of your ovum.
In in-vitro usually the dads are older so there would be more TCS. Is this true in your group? Are the dads who did IVF over 32?
Here is an abstract of an old study. 1: J Pediatr. 1975 Jan;86(1):84-8.Links
Older paternal age and fresh gene mutation: data on additional disorders.Jones KL, Smith DW, Harvey MA, Hall BD, Quan L.
Older paternal age has previously been documented as a factor in sporadic fresh mutational cases of several autosomal dominant disorders. In this collaborative study, an older mean paternal age has been documented in sporadic cases of at least five additional dominantly inheritable disorders; the basal cell nevus syndrome, the Waardenburg syndrome, the Crouzon syndrome, the oculo-dental-digital sysdrome, and the Treacher-Collins syndrome. It was also found to be a factor in acrodysostosis and progeria, suggesting a fresh mutant gene etiology for these two conditions in which virtually all cases have been sporadic and the mode of genetic etiology has been unknown.
I hope this helps. Older paternal age causes new genetic illnesses in offspring on a population level and sometime these illnesses don't show up until later in a person's life or in future generations. It would be helpful if knowledge of the male biological clock/new genetic mutations was honestly conveyed to the public. It is not.
I hope this make some sense.
~ Concerned
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