The results indicate that advanced paternal age at conception has negative long-term effects on reproductive fitness and longevity of offspring

Biol Reprod. 2008 Oct 15. [Epub ahead of print]
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Delayed Fatherhood in Mice Decreases Reproductive Fitness and Longevity of Offspring.
García-Palomares S, Navarro S, Pertusa JF, Hermenegildo C, García-Pérez MA, Rausell F, Cano A, Tarín JJ.
This study aims to analyze, in mice, the long-term effects of delayed fatherhood on reproductive fitness and longevity of offspring. Hybrid parental-generation (F0) males, at the age of 12, 70, 100, and 120 weeks, were individually housed with a randomly-selected 12 week-old hybrid female. The reproductive fitness of first-generation (F1) females was tested from the age of 25 weeks until the end of their reproductive life. In F1 males, the testing period ranged from the age of 52 weeks until death. Breeding F1 females from the 120-week group displayed interbirth intervals longer than females from the 12-, 70- and 100-week groups. Furthermore, F2 pups begotten by F1 studs exhibited weaning weights lower than pups from the 12- and 70-week groups. Offspring from the 120-week group exhibited shorter survival times associated with lower incidence of tumorigenesis and higher loss of body weight when approaching death when compared to F1 offspring from younger age groups. The results indicate that advanced paternal age at conception has negative long-term effects on reproductive fitness and longevity of offspring in the mouse model.
PMID: 18923156 [PubMed - as supplied by publisher]