Friday, February 19, 2010

Paternal age and mortality in nonaffective psychosis

Schizophr Res. 2010 Feb 16. [Epub ahead of print]

Paternal age and mortality in nonaffective psychosis.
Miller B, Pihlajamaa J, Haukka J, Cannon M, Henriksson M, Heilä H, Huttunen M, Tanskanen A, Lönnqvist J, Suvisaari J, Kirkpatrick B.

Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta, Georgia, United States; Department of Psychiatry, University of Oulu, Oulu, Finland.

INTRODUCTION: Advanced paternal age (APA) is associated with an increased mortality in the general population, and is a risk factor for schizophrenia. We aimed to test if APA is associated with increased mortality in people with nonaffective psychosis. METHODS: Subjects with nonaffective psychosis who were born in Helsinki, Finland, between 1951 and 1960 (n=529) were followed until June 2006 (age 46 to 55). Hazard ratios were calculated, adjusting for subject age, age of the other parent, and gender. RESULTS: In females but not males, there was a significant increase in all-causes mortality (HR=7.04, 95% CI 1.60-31.04, p=0.01) and natural deaths (HR=7.64, 95% CI 1.20-48.66, p=0.03) in offspring of fathers age >/=40, after adjustment for potential confounders. In males but not females, there was a significant decrease in suicides (HR=0.89, 95% CI 0.81-0.97, p=0.01) with increasing maternal age (as a continuous variable). In the entire sample, there was also a trend for decreased all-cause mortality (HR=0.96, 95% CI 0.92-1.01, p=0.08) with increasing maternal age (as a continuous variable). DISCUSSION: Both paternal and maternal age may affect mortality risk in offspring with psychosis. The specific disorders and pathway(s) associated with the increase in natural cause mortality remain to be determined. Copyright © 2010 Elsevier B.V. All rights reserved.

PMID: 20163936 [PubMed - as supplied by publisher]

Supplemental ContentRelated articles
Paternal and maternal ages at conception and risk of bipolar affective disorder in their offspring.
Psychol Med. 2010 Mar; 40(3):477-85. Epub 2009 Jul 23.
[Psychol Med. 2010]
Maternal age and paternal age are associated with distinct childhood behavioural outcomes in a general population birth cohort.
Schizophr Res. 2009 Dec; 115(2-3):130-5. Epub 2009 Sep 24.
[Schizophr Res. 2009]
The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study.
BMJ. 2009 Dec 22; 339:b5043. Epub 2009 Dec 22.
[BMJ. 2009]
[Cause of mortality in schizophrenic patients: prospective study of years of a cohort of 150 chronic schizophrenic patients]
Encephale. 2000 Nov-Dec; 26(6):32-41.
[Encephale. 2000]
ReviewPrevention of suicide and attempted suicide in Denmark. Epidemiological studies of suicide and intervention studies in selected risk groups.
Dan Med Bull. 2007 Nov; 54(4):306-69.
[Dan Med Bull. 2007]
» See reviews... | » See all...
Recent activity
Clear Turn Off Turn On Paternal age and mortality in nonaffective psychosis.Paternal age and mortality in nonaffective psychosis.Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

» See more...


Thursday, February 18, 2010

Tick tock goes the male biological clock