Wednesday, June 30, 2010

There was a statistically significant increase in the odds of Klinefelter syndrome with increasing paternal age

Arch Dis Child. 2010 Jun 28. [Epub ahead of print]

Case-control analysis of paternal age and trisomic anomalies.
De Souza E, Morris JK; EUROCAT Working Group.

Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Wolfson Institute of Preventive Medicine, Charterhouse Square, London, UK.

Abstract
Objectives To determine whether older paternal age increases the risk of fathering a pregnancy with Patau (trisomy 13), Edwards (trisomy 18), Klinefelter (XXY) or XYY syndrome. Design Case-control: cases with each of these syndromes were matched to four controls with Down syndrome from within the same congenital anomaly register and with maternal age within 6 months. Setting Data from 22 EUROCAT congenital anomaly registers in 12 European countries. Participants Diagnoses with observed or (for terminations) predicted year of birth from 1980 to 2005, comprising live births, fetal deaths with gestational age >/=20 weeks and terminations after prenatal diagnosis of the anomaly. Data include 374 cases of Patau syndrome, 929 of Edwards syndrome, 295 of Klinefelter syndrome, 28 of XYY syndrome and 5627 controls with Down syndrome. Main outcome measures Odds ratio (OR) associated with a 10-year increase in paternal age for each anomaly was estimated using conditional logistic regression. Results were adjusted to take account of the estimated association of paternal age with Down syndrome (1.11; 95% CI 1.01 to 1.23). Results The OR for Patau syndrome was 1.10 (95% CI 0.83 to 1.45); for Edwards syndrome, 1.15 (0.96 to 1.38); for Klinefelter syndrome, 1.35 (1.02 to 1.79); and for XYY syndrome, 1.99 (0.75 to 5.26). Conclusions There was a statistically significant increase in the odds of Klinefelter syndrome with increasing paternal age. The larger positive associations of Klinefelter and XYY syndromes with paternal age compared with Patau and Edwards syndromes are consistent with the greater percentage of these sex chromosome anomalies being of paternal origin.

PMID: 20584846 [PubMed - as supplied by publisher]

Supplemental ContentRelated citations
Trisomy 18 in Kuwait. [Int J Epidemiol. 1999]
Trisomy 18 in Kuwait.
Naguib KK, Al-Awadi SA, Moussa MA, Bastaki L, Gouda S, Redha MA, Mustafa F, Tayel SM, Abulhassan SA, Murthy DS.
Int J Epidemiol. 1999 Aug; 28(4):711-6. Down syndrome and paternal age, a new analysis of case-control data collected in the 1960s. [Am J Med Genet A. 2009]
Down syndrome and paternal age, a new analysis of case-control data collected in the 1960s.
De Souza E, Alberman E, Morris JK.
Am J Med Genet A. 2009 Jun; 149A(6):1205-8. Maternal age-specific risk of non-chromosomal anomalies. [BJOG. 2009]
Maternal age-specific risk of non-chromosomal anomalies.
Loane M, Dolk H, Morris JK, EUROCAT Working Group.
BJOG. 2009 Jul; 116(8):1111-9. Epub 2009 May 29.[Prenatal diagnostics of chromosomal aberrations Czech Republic: 1994-2007] [Ceska Gynekol. 2009]
[Prenatal diagnostics of chromosomal aberrations Czech Republic: 1994-2007]
Gregor V, Sípek A, Sípek A Jr, Horácek J, Langhammer P, Petrzílková L, Calda P.
Ceska Gynekol. 2009 Feb; 74(1):44-54. Review Epidemiology of double aneuploidies involving chromosome 21 and the sex chromosomes. [Am J Med Genet A. 2005]
Review Epidemiology of double aneuploidies involving chromosome 21 and the sex chromosomes.
Kovaleva NV, Mutton DE.
Am J Med Genet A. 2005 Apr 1; 134A(1):24-32. See reviews...

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14 Comments:

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