AGE OF THE FATHER AND THE HEALTH OF FUTURE GENERATIONS
Leslie B. Raschka, MD: "The age of the father is an important determinant of the health of future generations. Children conceived by fathers older than 34 years of age are at increased risk for genetic illness due to recent mutation in the male germ cell. The ageing process in the male is an important, probably the most important, cause of genetic illness in human populations."
Friday, August 24, 2012
Rate of de novo mutations and the importance of father's age to disease risk. Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, Thorleifsson G, Gudbjartsson DF, Helgason A, Magnusson OT, Thorsteinsdottir U, Stefansson K. Nature. 2012 Aug 22;488(7412):471-5. doi: 10.1038/nature11396. PMID: 22914163 [PubMed - in process]
Rate of de novo mutations and the importance of father's age to disease risk. Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G, Gudjonsson SA, Sigurdsson A, Jonasdottir A, Jonasdottir A, Wong WS, Sigurdsson G, Walters GB, Steinberg S, Helgason H, Thorleifsson G, Gudbjartsson DF, Helgason A, Magnusson OT, Thorsteinsdottir U, Stefansson K. Nature. 2012 Aug 22;488(7412):471-5. doi: 10.1038/nature11396. PMID: 22914163 [PubMed - in process]