Wednesday, August 04, 2010

Paternal age increases the risk for autism in an Iranian population sample.

Mol Autism. 2010 Feb 22;1(1):2.

Paternal age increases the risk for autism in an Iranian population sample.
Sasanfar R, Haddad SA, Tolouei A, Ghadami M, Yu D, Santangelo SL.

Department of Psychiatry, Harvard Medical School, Boston, MA, USA. ssantangelo@pngu.mgh.harvard.edu.

Abstract
ABSTRACT: BACKGROUND: Autism is a neurodevelopmental disorder which is known to have a strong genetic component and is most likely oligogenic. However, the necessary role of environmental factors has been well documented. Prior research suggests that parental characteristics, such as age and level of education, may be associated with a risk of autism. Parental age has been shown to be associated with many disorders, such as schizophrenia, childhood cancer and fetal death. However, results from studies of parental age and autism are inconsistent. METHODS: In the present study, we investigated the association of autism with parental age in 179 autism cases and 1611 matched cohort children from Iran. Each case was matched with nine cohort controls on parental education, sex, order of birth, consanguineous marriage, urbanism and province of residence. The Cox regression model was used to carry out conditional logistic regression on the matched data. RESULTS: There was a significant association between higher paternal age, but not maternal age, and an increasing risk of autism. An analysis of the combined effect of parental age and education also revealed that parents with higher education had an increased risk of having autistic children, with a dose-response effect of parental age. CONCLUSIONS: This study, which is the first epidemiological study of autism in Iran, provides evidence of the association of paternal age and risk of autism.

PMID: 20678245 [PubMed - in process]

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6 Comments:

At 6:10 PM , Blogger 王丁佳燕文均 said...

良言一句三冬暖,惡語傷人六月寒。......................................................................

 
At 6:04 AM , Blogger 红十字 said...

人不能像動物一樣活著,而應該追求知識和美德............................................................

 
At 8:00 PM , Blogger 姿宥美岑軒英 said...

人若賺得全世界,賠上自己的靈魂,有什麼益處?......................................................

 
At 2:41 AM , Blogger 守何何何韋 said...

我在戀愛著?--------是的,因為我在等待著.....................................................................

 
At 3:31 AM , Blogger 阮艳 said...

生命的意義,是在於活的充實;而不是在於活得長久。............................. ...................................

 
At 3:30 PM , Blogger 阿袁袁袁袁華 said...

在莫非定律中有項笨蛋定律:「一個組織中的笨蛋,恆大於等於三分之二。」..................................................

 

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